SCHEMBL8570722

SCHEMBL8570722

CCCn1cnc(C(N)=O)c1N

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.51
LMNA P02545 1/20 0.51
ADORA2A P29274 2/20 0.41
ADORA2B P29275 1/20 0.41
ADORA1 P30542 1/20 0.41
CDK1 P06493 1/20 0.40
CCNB1 P14635 1/20 0.40
CCNE1 P24864 1/20 0.40
CDK2 P24941 1/20 0.40
CYP2C19 P33261 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
KDM4E B2RXH2 1/20 0.40
TP53 P04637 1/20 0.40
MAPT P10636 1/20 0.40
MEN1 O00255 1/20 0.39
PABPC1 P11940 1/20 0.39
KMT2A Q03164 1/20 0.39
PDE4A P27815 1/20 0.38
PDE4B Q07343 1/20 0.38
PDE4C Q08493 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3465048 0.90 ALDH1A1 (0.49) ALDH1A1LMNAADORA2AADORA2BTDP1
SCHEMBL28314802 0.86 CYP2C19 (0.43) ALDH1A1LMNAADORA2AADORA2BADORA1
SCHEMBL3452770 0.86 ALDH1A1 (0.54) ALDH1A1LMNAADORA2AADORA1CDK1
SCHEMBL18050889 0.83 MEN1 (0.42) ALDH1A1LMNAADORA2AADORA2BADORA1
SCHEMBL3174463 0.81 ALDH1A1 (0.43) ALDH1A1LMNAADORA2AADORA1KDM4E
SCHEMBL6763636 0.78 ALDH1A1 (0.46) ALDH1A1LMNAADORA2AADORA1CCNE1
SCHEMBL6024012 0.77 LMNA (0.49) ALDH1A1LMNAADORA2AADORA1CCNE1
SCHEMBL7985623 0.76 ADORA2A (0.45) ADORA2AADORA2BADORA1CDK1CCNB1
SCHEMBL2112227 0.76 ALDH1A1 (0.59) ALDH1A1LMNAADORA2AADORA1CDK1
SCHEMBL9367320 0.75 ALDH1A1 (0.35) ALDH1A1LMNAADORA2AADORA2BADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5734053-A CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS PFIZER INC (US) 1998-03-31 US disclosed
EP-0647227-B1 PURINONE ANTIANGINAL AGENTS PFIZER LTD (GB) 1996-10-09 EP disclosed
EP-0464112-B1 A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS GEA FARMACEUTISK FABRIK AS (DK) 1994-10-05 EP disclosed
EP-0464112-A1 A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS. GEA FARMACEUTISK FABRIK AS (DK) 1992-01-08 EP disclosed
WO-1990011283-A1 A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS A/S GEA FARMACEUTISK FABRIK (DK) 1990-10-04 WO disclosed