Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 7/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480514 | 0.85 | APP (0.52) | APPNPC1ALDH1A1MAPTHPGD | |
| SCHEMBL31055984 | 0.85 | APP (0.52) | PTGER1APPNPC1HPGDRAB9A | |
| SCHEMBL2290346 | 0.84 | TRPM8 (0.55) | PTGER1APPNPC1HTTKMT2A | |
| SCHEMBL31056340 | 0.83 | APP (0.58) | APPNPC1ALDH1A1HPGDHTT | |
| SCHEMBL8571163 | 0.83 | TSHR (0.49) | NPC1ALDH1A1MAPTHPGDHTT | |
| SCHEMBL9789583 | 0.82 | PTGER1 (0.61) | PTGER1HPGDKMT2ALRRK2CYP2C9 | |
| SCHEMBL4722050 | 0.81 | PTGER1 (0.64) | PTGER1MAPTSMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL29836110 | 0.81 | PTGER1 (0.64) | PTGER1MAPTSMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL487486 | 0.81 | PTGER1 (0.75) | PTGER1ALDH1A1L3MBTL1KMT2ALRRK2 | |
| SCHEMBL2114834 | 0.81 | PTGER1 (0.53) | PTGER1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |