Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 13/20 | 0.52 |
| ▸ | CA2 | P00918 | 13/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 10/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4172084 | 0.80 | HTT (0.50) | GAATSHRMAPTHDAC6 | |
| SCHEMBL8574757 | 0.80 | GAA (0.48) | CA1CA2CA4GAACES2 | |
| SCHEMBL8572286 | 0.79 | HDAC1 (0.44) | CA1CA2CA4GAAPOLB | |
| SCHEMBL9425021 | 0.77 | CA1 (0.52) | CA1CA2CA4GAACA9 | |
| SCHEMBL1004213 | 0.77 | GAA (0.45) | GAACES2CES1HDAC1HDAC6 | |
| SCHEMBL7981473 | 0.77 | CES2 (0.56) | CA2GAACES2CES1TSHR | |
| SCHEMBL8570975 | 0.75 | GAA (0.40) | GAAPOLBTSHRMAPTHDAC1 | |
| SCHEMBL8571937 | 0.74 | TAS1R3 (0.57) | — | |
| SCHEMBL6392912 | 0.74 | GAA (0.52) | GAAPOLBCES2CES1MAPT | |
| SCHEMBL15594366 | 0.74 | CREBBP (0.44) | GAAHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |