Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27473460 | 0.80 | MTNR1A (0.65) | MTNR1AMTNR1B | |
| SCHEMBL8570951 | 0.79 | MTNR1A (0.62) | MTNR1ATDP1MTNR1BKCNH2 | |
| SCHEMBL8858486 | 0.78 | MTNR1A (0.79) | MTNR1AMTNR1B | |
| SCHEMBL8858577 | 0.78 | MTNR1A (0.77) | MTNR1AMTNR1B | |
| SCHEMBL8037757 | 0.78 | MTNR1A (0.62) | MTNR1AMTNR1B | |
| SCHEMBL30692247 | 0.77 | MTNR1A (0.64) | MTNR1ATDP1MTNR1B | |
| SCHEMBL3914252 | 0.77 | MTNR1A (0.64) | MTNR1ATDP1MTNR1B | |
| SCHEMBL9127163 | 0.77 | MTNR1A (0.79) | MTNR1AMTNR1B | |
| SCHEMBL4749622 | 0.76 | MTNR1A (0.63) | MTNR1ATDP1MTNR1B | |
| SCHEMBL27358867 | 0.75 | MTNR1A (0.59) | MTNR1AMTNR1BMAOBABL1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |