Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570925 | 0.81 | MTNR1A (0.63) | MTNR1AMTNR1BTDP1MEN1LMNA | |
| SCHEMBL8576193 | 0.79 | MTNR1A (0.69) | MTNR1AMTNR1BTDP1 | |
| SCHEMBL8571135 | 0.79 | MTNR1A (0.66) | MTNR1AMTNR1BTDP1 | |
| SCHEMBL8570983 | 0.79 | MTNR1A (0.65) | MTNR1AMTNR1BTDP1KCNH2 | |
| SCHEMBL3914252 | 0.78 | MTNR1A (0.64) | MTNR1AMTNR1BTDP1 | |
| SCHEMBL30692247 | 0.78 | MTNR1A (0.64) | MTNR1AMTNR1BTDP1 | |
| SCHEMBL8031027 | 0.77 | MTNR1A (0.59) | MTNR1AMTNR1BSLC6A2SLC6A4HTR3A | |
| SCHEMBL8573031 | 0.77 | MTNR1A (0.70) | MTNR1AMTNR1B | |
| SCHEMBL4749622 | 0.77 | MTNR1A (0.63) | MTNR1AMTNR1BTDP1 | |
| SCHEMBL8575242 | 0.76 | MTNR1A (0.69) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |