Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PRKCA | P17252 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429302 | 0.89 | PARP1 (0.36) | PARP1ALDH1A1TSHRCYP4F2CYP4A11 | |
| SCHEMBL8565163 | 0.82 | TP53 (0.30) | — | |
| SCHEMBL17775400 | 0.82 | PTPN1 (0.31) | ALDH1A1 | |
| SCHEMBL8569113 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNA | |
| SCHEMBL17779666 | 0.80 | CYP2C19 (0.36) | ALDH1A1TSHRCYP2D6KDM4ELMNA | |
| SCHEMBL8567197 | 0.78 | CYP2C19 (0.33) | ALDH1A1TSHRCYP2D6 | |
| SCHEMBL10477317 | 0.76 | CYP1A2 (0.39) | PARP1ALDH1A1TSHRCYP4F2CYP4A11 | |
| SCHEMBL28129931 | 0.76 | SIRT2 (0.39) | PRKCA | |
| SCHEMBL10502950 | 0.75 | KMT2A (0.38) | ALDH1A1TSHRCYP2D6KDM4E | |
| SCHEMBL10505164 | 0.75 | KMT2A (0.38) | ALDH1A1TSHRCYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35865-E | Preparation of glutaric acid derivatives | PFIZER INC. (US) | 1998-07-28 | — | — | US | disclosed |
| US-5714628-A | CARBOXYLATION A CYCLOHEXANONES TO A CYCLOPENTANECARBOXYLIC ACIDS WITH HYDROGEN PEROXIDE | PFIZER, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0391673-B2 | Preparation of glutaric acid derivatives | PFIZER LTD (GB) | 1997-04-02 | — | — | EP | disclosed |
| US-5166406-A | Peroxidation of cyclohexanone derivatives | PFIZER INC. (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0391673-A1 | Preparation of glutaric acid derivatives | Pfizer Limited (GB) | 1990-10-10 | — | — | EP | disclosed |