Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6392944 | 0.86 | PLK1 (0.60) | PLK1SMN1; SMN2MAPTTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27655722 | 0.84 | PLK1 (0.58) | PLK1SMN1; SMN2MAPTTDP1ALDH1A1 | |
| SCHEMBL24136599 | 0.82 | LMNA (0.55) | SMN1; SMN2LMNAMAPK1MAPTTDP1 | |
| SCHEMBL30466421 | 0.82 | LMNA (0.55) | SMN1; SMN2LMNAMAPK1MAPTTDP1 | |
| SCHEMBL2425023 | 0.80 | MAPT (0.68) | SMN1; SMN2LMNAMAPK1MAPTTDP1 | |
| SCHEMBL10740410 | 0.80 | LMNA (0.56) | SMN1; SMN2LMNAMAPK1MAPTTDP1 | |
| SCHEMBL30466426 | 0.80 | MAPT (0.68) | SMN1; SMN2LMNAMAPK1MAPTTDP1 | |
| SCHEMBL15621232 | 0.78 | PLK1 (0.55) | PLK1LMNAMAPK1MAPTTDP1 | |
| SCHEMBL8577022 | 0.78 | PLK1 (0.55) | PLK1SMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL21690548 | 0.78 | PLK1 (0.51) | PLK1SMN1; SMN2MAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |