SCHEMBL857340

SCHEMBL857340

COC(=O)[C@H]1C(C(=O)NCc2ccc(C(C)=O)o2)[C@@H]2C=C[C@H]1C21CC1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 20/20 0.66
FPR3 P25089 17/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2682169 1.00 FPR2 (0.66) FPR2FPR3
SCHEMBL2681903 0.89 FPR2 (0.68) FPR2FPR3
SCHEMBL855165 0.89 FPR2 (0.68) FPR2FPR3
SCHEMBL855025 0.85 FPR2 (0.66) FPR2FPR3
SCHEMBL2684098 0.85 FPR2 (0.66) FPR2FPR3
SCHEMBL2682652 0.80 FPR3 (1.00) FPR2FPR3
SCHEMBL2682456 0.76 FPR2 (0.68) FPR2FPR3
SCHEMBL856945 0.74 FPR2 (0.65) FPR2FPR3
SCHEMBL2682060 0.74 FPR2 (0.65) FPR2FPR3
SCHEMBL2683287 0.73 FPR3 (0.74) FPR2FPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2432760-A1 BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS Actelion Pharmaceuticals Ltd. (CH) 2012-03-28 EP disclosed