Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359327 | 0.83 | PDE4D (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1553518 | 0.82 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1553615 | 0.79 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL1553474 | 0.79 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL1552800 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8570416 | 0.78 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL1554630 | 0.77 | GAA (0.46) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8570317 | 0.76 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL1552847 | 0.76 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL1553637 | 0.76 | ALDH1A1 (0.45) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |