Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 1.00 |
| ▸ | SRC | P12931 | 1/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | ABL2 | P42684 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578711 | 0.88 | EGFR (0.78) | EGFRSRCABL1ABL2CHEK1 | |
| SCHEMBL8574371 | 0.87 | EGFR (1.00) | EGFRSRCABL1ABL2CHEK1 | |
| SCHEMBL8572719 | 0.84 | EGFR (0.73) | EGFRSRCABL1ABL2ALOX15 | |
| SCHEMBL8575803 | 0.84 | EGFR (0.73) | EGFRSRCABL1ABL2CHEK1 | |
| SCHEMBL8574510 | 0.83 | EGFR (0.70) | EGFRSRCABL1ABL2ALOX15 | |
| SCHEMBL4353399 | 0.75 | EGFR (0.66) | EGFRSRCABL1ABL2BRAF | |
| SCHEMBL4359046 | 0.74 | EGFR (0.80) | EGFRSRCCHEK1WEE1ALOX12 | |
| SCHEMBL4348516 | 0.74 | EGFR (0.58) | EGFRSRCABL1ABL2CHEK1 | |
| SCHEMBL31060869 | 0.74 | EGFR (1.00) | EGFRSRCABL1ABL2ALOX15 | |
| SCHEMBL3355884 | 0.74 | EGFR (1.00) | EGFRSRCABL1ABL2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998017662-A1 | PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | claimed |
| WO-1998017662-A1 | PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | disclosed |