Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.73 |
| ▸ | SRC | P12931 | 1/20 | 0.73 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574541 | 0.84 | EGFR (1.00) | EGFRSRCABL1ABL2PIK3CA | |
| SCHEMBL4353399 | 0.80 | EGFR (0.66) | EGFRSRCABL1ABL2MEN1 | |
| SCHEMBL8574371 | 0.79 | EGFR (1.00) | EGFRSRCABL1ABL2CHEK1 | |
| SCHEMBL4348516 | 0.79 | EGFR (0.58) | EGFRSRCABL1ABL2PIK3CA | |
| SCHEMBL8578711 | 0.71 | EGFR (0.78) | EGFRSRCABL1ABL2ALOX15 | |
| SCHEMBL11190933 | 0.70 | EGFR (0.52) | EGFRSRCABL1ABL2PIK3CA | |
| SCHEMBL8572719 | 0.68 | EGFR (0.73) | EGFRSRCABL1ABL2ALOX15 | |
| SCHEMBL4359046 | 0.67 | EGFR (0.80) | EGFRSRCALOX12CHEK1WEE1 | |
| SCHEMBL8574510 | 0.67 | EGFR (0.70) | EGFRSRCABL1ABL2PIK3CA | |
| SCHEMBL30695578 | 0.66 | ASH1L (0.59) | EGFRSRCMEN1KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998017662-A1 | PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | claimed |