Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 1.00 |
| ▸ | SRC | P12931 | 1/20 | 0.76 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359046 | 0.89 | EGFR (0.80) | EGFRSRCALDH1A1LMNANPC1 | |
| SCHEMBL8574541 | 0.87 | EGFR (1.00) | EGFRSRCABL1ABL2ALDH1A1 | |
| SCHEMBL4358045 | 0.86 | EGFR (0.76) | EGFRSRCALDH1A1LMNANPC1 | |
| SCHEMBL4361477 | 0.85 | EGFR (0.73) | EGFRSRCPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7256744 | 0.83 | EGFR (0.70) | EGFRSRCPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4353399 | 0.80 | EGFR (0.66) | EGFRSRCABL1ABL2ALDH1A1 | |
| SCHEMBL8575803 | 0.79 | EGFR (0.73) | EGFRSRCABL1ABL2MEN1 | |
| SCHEMBL8576451 | 0.76 | EGFR (1.00) | EGFRSRCABL1ABL2NPC1 | |
| SCHEMBL8578711 | 0.75 | EGFR (0.78) | EGFRSRCABL1ABL2ALDH1A1 | |
| SCHEMBL8577298 | 0.73 | EGFR (0.78) | EGFRSRCABL1ABL2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998017662-A1 | PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | claimed |
| WO-1998017662-A1 | PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE | NOVARTIS AG (CH) | 1998-04-30 | — | — | WO | disclosed |