Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729316 | 0.81 | PTGS2 (0.60) | PTGS2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL5730934 | 0.76 | PTGS2 (0.54) | PTGS2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL28805031 | 0.74 | PTGS2 (0.53) | PTGS2MAPTPTGS1PDE3A | |
| SCHEMBL2760349 | 0.74 | PTGS2 (1.00) | PTGS2PTGS1PDE3A | |
| SCHEMBL5585925 | 0.72 | ALDH1A1 (0.46) | PTGS2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL12987691 | 0.71 | PTGS2 (0.56) | PTGS2NPSR1MEN1KMT2A | |
| SCHEMBL2776545 | 0.70 | TARBP2 (0.54) | PTGS2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL5729672 | 0.70 | PTGS2 (0.70) | PTGS2PTGS1PDE3A | |
| SCHEMBL4221887 | 0.70 | MEN1 (0.55) | PTGS2RAB9ANPSR1MEN1KMT2A | |
| SCHEMBL4029497 | 0.70 | PTGS2 (0.64) | PTGS2NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015541-A1 | NOVEL ISOXAZOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS | EGIS Gyógyszergyár Rt. (HU) | 1998-04-16 | — | — | WO | disclosed |