Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1931120 | 0.81 | SLC22A12 (0.51) | MAPK1CYP3A4TSHRCYP1A2ADRB2 | |
| SCHEMBL18930745 | 0.79 | PRKACA (0.40) | MAPK1CYP3A4TSHRCYP1A2ADRB2 | |
| SCHEMBL2371118 | 0.78 | ALOX15 (0.39) | MAPK1CYP3A4CYP1A2KDM4EALDH1A1 | |
| SCHEMBL29634742 | 0.78 | ALOX15 (0.39) | MAPK1CYP3A4CYP1A2KDM4EALDH1A1 | |
| SCHEMBL286459 | 0.78 | AR (0.51) | KDM4EALDH1A1USP2ALOX15ALOX12 | |
| Hydrochloric Acid SCHEMBL21144975 | 0.78 | PRKACA (0.40) | MAPK1CYP3A4TSHRCYP1A2ADRB2 | |
| Hydrochloric Acid SCHEMBL21144976 | 0.78 | PRKACA (0.40) | MAPK1CYP3A4TSHRCYP1A2ADRB2 | |
| SCHEMBL10971792 | 0.77 | CYP2A6 (0.47) | CYP3A4TSHRCYP1A2KDM4EALDH1A1 | |
| SCHEMBL22939708 | 0.76 | GAA (0.44) | CYP3A4TSHRKDM4EALDH1A1USP2 | |
| SCHEMBL1908021 | 0.75 | TRPA1 (0.38) | MAPK1CYP3A4TSHRCYP1A2ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |