Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571260 | 0.97 | MAPT (0.40) | MAPTMAPK1MAOBMAOAROCK2 | |
| SCHEMBL8671822 | 0.95 | MAPT (0.41) | MAPTMAPK1MAOBMAOAROCK2 | |
| SCHEMBL8601582 | 0.93 | MAPT (0.41) | MAPTMAPK1MAOBMAOAPRMT5 | |
| SCHEMBL8569752 | 0.92 | MAPT (0.40) | MAPTMAPK1MAOBMAOAPRMT5 | |
| SCHEMBL8598873 | 0.91 | ADORA3 (0.40) | MAPTMAPK1MAOBMAOANPC1 | |
| SCHEMBL2528009 | 0.90 | PDE9A (0.42) | MAPTMAPK1MAOBMAOASTK10 | |
| SCHEMBL8603781 | 0.89 | MAPT (0.42) | MAPTMAPK1MAOBMAOAPRMT5 | |
| SCHEMBL8600361 | 0.88 | PDE4A (0.38) | MAPTMAPK1MAOBMAOAPRMT5 | |
| SCHEMBL8574117 | 0.88 | TDP2 (0.39) | MAPTMAPK1MAOBMAOAKDM4E | |
| SCHEMBL8572042 | 0.88 | PRMT5 (0.48) | MAPTMAPK1MAOBMAOAPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |