SCHEMBL8576404

SCHEMBL8576404

Nc1ccc([N+](=O)[O-])cc1SSc1cc([N+](=O)[O-])ccc1N

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.60
THRB P10828 1/20 0.60
TDP1 Q9NUW8 6/20 0.59
ALDH1A1 P00352 5/20 0.57
CYP3A4 P08684 3/20 0.57
TSHR P16473 3/20 0.55
PDE7A Q13946 2/20 0.53
HTT P42858 1/20 0.52
TXNRD1 Q16881 1/20 0.50
TXNRD3 Q86VQ6 1/20 0.50
TXNRD2 Q9NNW7 1/20 0.50
ALOX15 P16050 1/20 0.50
G6PD P11413 1/20 0.48
IDE P14735 1/20 0.48
HSP90AA1 P07900 1/20 0.47
LMNA P02545 1/20 0.46
POLB P06746 1/20 0.46
APEX1 P27695 1/20 0.46
CASP6 P55212 1/20 0.46
CTDSP1 Q9GZU7 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9805799 0.86 GAA (0.63) GAATHRBTDP1ALDH1A1CYP3A4
SCHEMBL18567618 0.86 GAA (0.58) GAATHRBTDP1ALDH1A1CYP3A4
SCHEMBL11673035 0.80 TDP1 (0.55) GAATHRBTDP1ALDH1A1CYP3A4
SCHEMBL29353815 0.78 CYP3A4 (0.69) GAATHRBTDP1ALDH1A1CYP3A4
SCHEMBL78293 0.78 CYP3A4 (0.69) GAATHRBTDP1ALDH1A1CYP3A4
SCHEMBL5024770 0.78 HSD17B10 (0.64) GAATHRBTDP1ALDH1A1TSHR
SCHEMBL30388476 0.78 HSD17B10 (0.64) GAATHRBTDP1ALDH1A1TSHR
SCHEMBL14147098 0.78 ALDH1A1 (0.64) GAATHRBTDP1ALDH1A1CYP3A4
SCHEMBL499475 0.77 GAA (0.49) GAATHRBTDP1ALDH1A1CYP3A4
SCHEMBL11097307 0.77 GAA (0.53) GAATHRBTDP1ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10237058-A None JP disclosed
JP-H10237058-A 2,2'-BIS(5-OXOTETRAHYDROFURAN-2-CARBONYLAMINO)-5,5'-DINITRODIPHENYL DISULFIDE AND ITS PRODUCTION SUMITOMO CHEM CO LTD 1998-09-08 JP disclosed