Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18299029 | 1.00 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11051158 | 0.84 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11713802 | 0.84 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11051156 | 0.84 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11713819 | 0.84 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL23315374 | 0.84 | MAPT (0.41) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL11051159 | 0.84 | MAPT (0.38) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL18307342 | 0.83 | SLC6A1 (0.38) | SLC6A1GABRA5GABRB2SLC6A12SLC6A11 | |
| SCHEMBL5156420 | 0.83 | MAPT (0.37) | MAPTPKMPOLBSLC6A1GABRA5 | |
| SCHEMBL19895627 | 0.83 | MAPT (0.37) | MAPTPKMPOLBSLC6A1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210040062-A1 | AZOLE-SUBSTITUTED PYRIDINE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2021-02-11 | — | — | US | disclosed |
| EP-3418276-A1 | AZOLE-SUBSTITUTED PYRIDINE COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2018-12-26 | — | — | EP | disclosed |
| US-10100030-B2 | Carboxymethyl piperidine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2018-10-16 | — | — | US | disclosed |
| EP-3067349-B1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL (JP) | 2018-02-28 | — | — | EP | disclosed |
| EP-3067349-B1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL (JP) | 2018-02-28 | — | — | EP | disclosed |
| US-20160289206-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2016-10-06 | — | — | US | disclosed |
| US-20160289206-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2016-10-06 | — | — | US | disclosed |
| US-20160289206-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2016-10-06 | — | — | US | disclosed |
| EP-3067349-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | Kissei Pharmaceutical Co., Ltd. (JP) | 2016-09-14 | — | — | EP | disclosed |
| EP-3067349-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | Kissei Pharmaceutical Co., Ltd. (JP) | 2016-09-14 | — | — | EP | disclosed |
| WO-2016021562-A1 | CYANOTHIOPHENE DERIVATIVE | キッセイ薬品工業株式会社 | 2016-02-11 | — | — | WO | disclosed |
| WO-2015068744-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | キッセイ薬品工業株式会社 | 2015-05-14 | — | — | WO | disclosed |
| US-5846980-A | N-(benzhydryloxyalkyl)-4-(carboxy/carbamoyl methyl)-piperidine derivatives as antidepressants | COOPERATION PHARMACEUTIQUE FRANCAISE (FR) | 1998-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10100030-B2 | Carboxymethyl piperidine derivative | TACR1, CYP3A5, CNR1 | MAPT 4844/4885PKM 1253/4885POLB 2094/4885 |
| US-20210040062-A1 | AZOLE-SUBSTITUTED PYRIDINE COMPOUND | CYP2F1, CYP21A2, CYP11B1 | MAPT 4868/4885PKM 1884/4885POLB 4110/4885 |
| US-20160289206-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | TACR1, CYP3A5, CNR1 | MAPT 4844/4885PKM 1253/4885POLB 2094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.