Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.74 |
| ▸ | EDNRA | P25101 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315734 | 0.86 | EDNRB (1.00) | EDNRBEDNRAMEN1KMT2AUSP2 | |
| SCHEMBL8805019 | 0.84 | EDNRB (0.62) | EDNRBEDNRAMAPTTP53 | |
| SCHEMBL6314851 | 0.78 | EDNRB (0.75) | EDNRBEDNRAMEN1KMT2AUSP2 | |
| SCHEMBL8798028 | 0.78 | EDNRB (0.74) | EDNRBEDNRAMEN1KMT2AUSP2 | |
| SCHEMBL6314775 | 0.77 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL6315635 | 0.73 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL6321016 | 0.71 | EDNRB (0.77) | EDNRBEDNRA | |
| SCHEMBL7068846 | 0.71 | ALDH1A1 (0.47) | EDNRBEDNRAMEN1KMT2AUSP2 | |
| SCHEMBL8798982 | 0.70 | EDNRB (0.78) | EDNRBEDNRA | |
| SCHEMBL17242043 | 0.69 | MAPT (0.68) | EDNRBEDNRAMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731321-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-24 | — | — | US | disclosed |
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | disclosed |