Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.52 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804066 | 0.88 | EDNRB (0.79) | EDNRBTP53MAPTRXFP1EDNRA | |
| SCHEMBL8577181 | 0.84 | EDNRB (0.74) | EDNRBTP53MAPTEDNRA | |
| SCHEMBL6320723 | 0.74 | EDNRB (0.92) | EDNRB | |
| SCHEMBL8804891 | 0.71 | EDNRB (0.76) | EDNRB | |
| SCHEMBL6315734 | 0.69 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL1890347 | 0.68 | TP53 (0.67) | EDNRBTP53MAPTRXFP1 | |
| SCHEMBL6314851 | 0.65 | EDNRB (0.75) | EDNRBTP53MAPTEDNRA | |
| SCHEMBL7068846 | 0.64 | ALDH1A1 (0.47) | EDNRBEDNRA | |
| SCHEMBL8798028 | 0.64 | EDNRB (0.74) | EDNRBTP53MAPTEDNRA | |
| SCHEMBL6322007 | 0.64 | EDNRB (0.67) | EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700807-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |
| EP-0755934-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-01-29 | — | — | EP | disclosed |