Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 3/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934997 | 0.88 | SCN5A (0.51) | SCN5ASCN9AGRM5ALDH1A1USP2 | |
| SCHEMBL2740504 | 0.78 | SIGMAR1 (0.61) | SIGMAR1GRM5ALDH1A1USP2CYP3A4 | |
| SCHEMBL19404236 | 0.78 | CTNNB1 (0.53) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL223669 | 0.77 | SIGMAR1 (0.59) | SIGMAR1GRM5ALDH1A1USP2CYP3A4 | |
| SCHEMBL1375337 | 0.76 | SIGMAR1 (0.64) | SCN9ASIGMAR1ALDH1A1CYP3A4HPGD | |
| SCHEMBL851451 | 0.76 | SCN9A (0.63) | SCN9ASIGMAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL7718789 | 0.75 | SIGMAR1 (0.62) | SCN9ASIGMAR1ALDH1A1CYP3A4HPGD | |
| SCHEMBL226167 | 0.74 | SIGMAR1 (0.56) | SIGMAR1PKMTDO2HPGD | |
| SCHEMBL2336862 | 0.74 | SMN1; SMN2 (0.71) | SIGMAR1ALDH1A1USP2CYP3A4HPGD | |
| SCHEMBL24088883 | 0.73 | GABRD (0.52) | SIGMAR1PKMTDO2USP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068450-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |