Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 5/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273113 | 0.98 | ITGB3 (0.48) | ITGB3ITGA2BHDAC1DPP4S1PR1 | |
| Acetic Acid SCHEMBL7272501 | 0.84 | DPP4 (0.46) | ITGB3ITGA2BHDAC1DPP4 | |
| SCHEMBL7280721 | 0.81 | S1PR1 (0.54) | ITGB3ITGA2BHDAC1S1PR1 | |
| SCHEMBL7274316 | 0.81 | ITGB3 (0.61) | ITGB3ITGA2BHDAC1S1PR1 | |
| SCHEMBL9052848 | 0.81 | ITGB3 (0.55) | ITGB3ITGA2BHDAC1S1PR1 | |
| SCHEMBL7401407 | 0.80 | ITGB3 (0.50) | ITGB3ITGA2BHDAC1 | |
| Hydrochloric Acid SCHEMBL7404001 | 0.78 | F10 (0.51) | ITGB3ITGA2BHDAC1 | |
| SCHEMBL8540990 | 0.78 | F10 (0.52) | ITGB3ITGA2BS1PR1 | |
| SCHEMBL7405707 | 0.78 | ITGB3 (0.55) | ITGB3ITGA2B | |
| SCHEMBL7275468 | 0.77 | ITGB3 (0.53) | ITGB3ITGA2BHDAC1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |