Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28051360 | 0.96 | NPC1 (0.31) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL7197821 | 0.96 | NPC1 (0.32) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL6906693 | 0.96 | NPC1 (0.32) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL7575488 | 0.85 | — | — | |
| SCHEMBL6254543 | 0.83 | — | — | |
| SCHEMBL1025348 | 0.75 | NPC1 (0.32) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL11022343 | 0.73 | — | — | |
| SCHEMBL6252137 | 0.73 | — | — | |
| SCHEMBL1753874 | 0.73 | — | — | |
| SCHEMBL7624298 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753786-A | Process for transitioning between incompatible polymerization catalysts | EXXON CHEMICAL PATENTS INC. (US) | 1998-05-19 | — | — | US | disclosed |
| US-5747612-A | KILLING ZIEGLER-NATTA CATALYST AND ADDING METALLOCENE | EXXON CHEMICAL PATENTS INC. (US) | 1998-05-05 | — | — | US | disclosed |
| US-5672665-A | COORDINATION CATALYSTS, METALLOCENE CATALYSTS | EXXON CHEMICAL PATENTS, INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0751965-A1 | PROCESS FOR TRANSITIONING BETWEEN INCOMPATIBLE POLYMERIZATION CATALYSTS | EXXON CHEMICAL PATENTS INC. (US) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995026370-A1 | PROCESS FOR TRANSITIONING BETWEEN INCOMPATIBLE POLYMERIZATION CATALYSTS | EXXON CHEMICAL PATENTS INC. (US) | 1995-10-05 | — | — | WO | disclosed |
| US-5442019-A | Discontinuing first catalyst; supplying catalyst killer; supplying second catalyst | EXXON CHEMICAL COMPANY (US) | 1995-08-15 | — | — | US | disclosed |