Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312864 | 0.89 | PSEN1 (0.38) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL970762 | 0.84 | GRN (0.40) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL969137 | 0.84 | GRN (0.40) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL967760 | 0.84 | GRN (0.40) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3347419 | 0.84 | PSEN1 (0.39) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4430800 | 0.83 | CTSS (0.55) | RENCTSKCTSS | |
| SCHEMBL968972 | 0.83 | CYP2D6 (0.42) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL968973 | 0.83 | CYP2D6 (0.42) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3382250 | 0.82 | PSEN1 (0.37) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4433209 | 0.79 | REN (0.50) | CYP2D6RENBCHEMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776933-A | Method of inhibiting protease | E. R. SQUIBB & SONS, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5760036-A | ENZYME INHIBITORS OF RETROVIRAL PROTEASE FOR PREVENTION OF AIDS | E. R. SQUIBB & SONS, INC. (US) | 1998-06-02 | — | — | US | disclosed |