SCHEMBL8577931

SCHEMBL8577931

C(#Cc1ccc2c(c1)Cc1cc(C#Cc3ccccc3)ccc1-2)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 14/20 0.61
APP P05067 1/20 0.50
MAPT P10636 2/20 0.45
KDM4E B2RXH2 1/20 0.42
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
HPGD P15428 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
FFAR1 O14842 1/20 0.42
SRD5A2 P31213 1/20 0.42
HNF4A P41235 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8911138 0.94 GRM5 (0.56) GRM5APPMAPTKDM4ENPC1
SCHEMBL8912621 0.83 GRM5 (0.49) GRM5APPMAPTKDM4ENPC1
SCHEMBL17224541 0.82 KDM4E (0.47) GRM5MAPTKDM4ENPC1ALDH1A1
SCHEMBL10669403 0.81 GRM5 (0.62) GRM5APPMAPTFFAR1SRD5A2
SCHEMBL8580292 0.81 GRM5 (0.47) GRM5APPFFAR1
SCHEMBL29731284 0.80 SMN1; SMN2 (0.53) GRM5MAPTKDM4ENPC1ALDH1A1
SCHEMBL8581557 0.79 GRM5 (0.46) GRM5APPFFAR1
SCHEMBL4526679 0.78 GRM5 (0.60) GRM5APPMAPTFFAR1HNF4A
SCHEMBL22566782 0.77 CTDSP1 (0.50) GRM5ALDH1A1LMNAHPGD
Hydrochloric Acid SCHEMBL8580691 0.76 GRM5 (0.44) GRM5FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5703378-A Materials for the scavanging of hydrogen at high temperatures SANDIA CORPORATION (US) 1997-12-30 US claimed
US-5624598-A DOUBLE OR TRIPLE BOND HYDROCARBON COMPOUNDS. FOR HYDROGEN SCAVENGERS SHEPODD TIMOTHY J (US) 1997-04-29 US claimed
US-5830958-A Polynuclear metallocene preparation and use PHILLIPS PETROLEUM COMPANY (US) 1998-11-03 US disclosed
US-5703378-A Materials for the scavanging of hydrogen at high temperatures SANDIA CORPORATION (US) 1997-12-30 US disclosed
US-5624598-A DOUBLE OR TRIPLE BOND HYDROCARBON COMPOUNDS. FOR HYDROGEN SCAVENGERS SHEPODD TIMOTHY J (US) 1997-04-29 US disclosed