Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8578947 | 0.91 | PNMT (0.35) | PNMTNPC1RAB9ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL8581362 | 0.88 | PNMT (0.31) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8580445 | 0.84 | PNMT (0.31) | PNMTDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8679932 | 0.83 | PNMT (0.37) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL62724 | 0.80 | PNMT (0.39) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL7607951 | 0.80 | PNMT (0.39) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL6675358 | 0.79 | PNMT (0.38) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL6675362 | 0.79 | PNMT (0.38) | PNMTNPC1RAB9ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL9168322 | 0.78 | PNMT (0.37) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL8142261 | 0.76 | PNMT (0.35) | PNMTNPC1RAB9ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5830958-A | Polynuclear metallocene preparation and use | PHILLIPS PETROLEUM COMPANY (US) | 1998-11-03 | — | — | US | disclosed |
| US-5705578-A | Method for making and using a supported metallocene catalyst system | PHILLIPS PETROLEUM COMPANY (US) | 1998-01-06 | — | — | US | disclosed |