SCHEMBL8578908

SCHEMBL8578908

FC(F)(F)c1ccncc1C(OCc1ccccc1)c1cncnc1C1CC1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2D6 P10635 2/20 0.34
CYP2C19 P33261 2/20 0.34
USP2 O75604 1/20 0.34
ALDH1A1 P00352 1/20 0.34
ALOX15 P16050 1/20 0.34
MAPK1 P28482 1/20 0.34
RBP4 P02753 1/20 0.33
CYP11B2 P19099 1/20 0.31
OPRM1 P35372 1/20 0.30
KCNH2 Q12809 1/20 0.30
SIGMAR1 Q99720 1/20 0.30
ALOX5AP P20292 1/20 0.30
FEN1 P39748 1/20 0.30
USP1 O94782 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8441351 0.92 CYP3A4 (0.37) CYP1A2CYP3A4CYP2D6CYP2C19USP2
SCHEMBL8578758 0.74 CYP1A2 (0.37) CYP1A2CYP3A4CYP2D6CYP2C19USP2
SCHEMBL8547752 0.73 CNR2 (0.36) ALDH1A1
SCHEMBL8327164 0.71 CYP3A4 (0.36) CYP1A2CYP3A4CYP2D6CYP2C19USP2
SCHEMBL8578616 0.68 CYP1A2 (0.33) CYP1A2CYP3A4CYP2D6CYP2C19USP2
SCHEMBL8580020 0.67 TSHR (0.34) CYP1A2CYP3A4CYP2D6CYP2C19USP2
SCHEMBL23082972 0.65 KMT2A (0.44) ALDH1A1
SCHEMBL8684578 0.65 HTR1A (0.38) CYP1A2CYP3A4CYP2D6CYP2C19USP2
Benzyl Alcohol SCHEMBL27535788 0.64 CYP3A4 (0.38) CYP1A2CYP3A4CYP2D6CYP2C19USP2
SCHEMBL8581649 0.63 CYP1A2 (0.36) CYP1A2CYP3A4CYP2D6CYP2C19USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929510-A2 PROCESSES FOR THE PREPARATION OF ARYL-$g(b)-DIKETONES, ARYL-PYRIMIDINE KETONES AND CROP PROTECTION INTERMEDIATES ZENECA LIMITED (GB) 1999-07-21 EP disclosed
US-5925795-A Processes for the preparation of aryl-β-diketones, arylpyrimidine ketones and crop protection intermediates ZENECA LIMITED (GB) 1999-07-20 US disclosed
EP-0927169-A1 4-CYCLOALKYL-5-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL AS CROP PROTECTION AGENTS ZENECA LIMITED (GB) 1999-07-07 EP disclosed
WO-1998011046-A2 PROCESSES FOR THE PREPARATION OF ARYL-β-DIKETONES, ARYL-PYRIMIDINE KETONES AND CROP PROTECTION INTERMEDIATES ZENECA LIMITED (GB) 1998-03-19 WO disclosed
WO-1998011074-A1 4-CYCLOALKYL-5-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL AS CROP PROTECTION AGENTS ZENECA LIMITED (GB) 1998-03-19 WO disclosed
US-5707930-A HERBICIDES, AGRICULTURE ZENECA LIMITED (GB) 1998-01-13 US disclosed