Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 2/20 | 0.57 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | BLM | P54132 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | RGS12 | O14924 | 2/20 | 0.51 |
| ▸ | GMNN | O75496 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8579230 | 1.00 | GABBR2 (0.57) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL6937644 | 0.82 | GABBR2 (0.60) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL7824832 | 0.82 | GABBR2 (0.60) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL11303373 | 0.81 | GABBR2 (0.58) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL11303376 | 0.81 | GABBR2 (0.58) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL9684949 | 0.78 | GABBR2 (0.55) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL9580152 | 0.78 | GABBR2 (0.55) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL10494818 | 0.77 | GABBR2 (0.54) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL10967937 | 0.77 | GABBR2 (0.54) | GABBR2GABBR1MEN1CYP3A4MAPT | |
| SCHEMBL28419449 | 0.76 | EGFR (0.63) | GABBR2GABBR1MEN1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731336-A | USING ARYL-SUBSTITUTED RHODAMINES | ELI LILLY AND COMPANY (US) | 1998-03-24 | — | — | US | disclosed |
| US-5691367-A | ANTIINFLAMMATORY AGENTS OR ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0722729-A2 | Aryl-substituted rhodanines for treating multiple sclerosis | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5158966-A | Aryl-substituted rhodanine derivatives | THE UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0500337-A1 | Composition containing aryl-substituted rhodanine derivatives for the treatment of type I diabetes | UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-08-26 | — | — | EP | disclosed |
| EP-0391644-A2 | Aryl-substituted rhodanine derivatives | ELI LILLY AND COMPANY (US) | 1990-10-10 | — | — | EP | disclosed |
| EP-0211670-B1 | DI-T-BUTYLPHENOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1990-05-09 | — | — | EP | disclosed |
| EP-0211670-A2 | Di-t-butylphenol compounds | ELI LILLY AND COMPANY (US) | 1987-02-25 | — | — | EP | disclosed |