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Sugi Predict / Compounds / Enkephalin

Enkephalin

Enkephalin

SCHEMBL8580265

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O.O=C(O)C(F)(F)F

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ OPRD1 P41143 12/20 0.75
▸ OPRM1 P35372 7/20 0.67
▸ OPRK1 P41145 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Enkephalin SCHEMBL631959 0.95 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL631958 0.95 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL30857 0.95 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL11399380 0.95 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL16189980 0.95 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL25236888 0.95 OPRD1 (0.73) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL30400052 0.95 OPRD1 (0.73) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL29458101 0.94 OPRD1 (0.72) OPRD1OPRM1OPRK1
SCHEMBL29355873 0.94 OPRD1 (0.73) OPRD1OPRM1OPRK1
SCHEMBL8077734 0.90 OPRD1 (0.73) OPRD1OPRM1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5712367-A COUPLING WITH LIPOPHILIC SUBSTITUENT RHONE-POULENC CHIMIE (FR) 1998-01-27 — — US disclosed