Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3044369 | 0.75 | MAPT (0.50) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL23673718 | 0.72 | IDO1 (0.50) | IDO1GAAMAPTMEN1KMT2A | |
| SCHEMBL27406608 | 0.71 | IDO1 (0.38) | IDO1GAAMAPTMEN1KMT2A | |
| SCHEMBL27713636 | 0.71 | IDO1 (0.44) | IDO1GAAMAPTMEN1KMT2A | |
| SCHEMBL31536408 | 0.68 | TSHR (0.41) | GAAMEN1KMT2AHSD17B10GLA | |
| SCHEMBL8143860 | 0.65 | TNKS2 (0.56) | GAAMAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL31297773 | 0.65 | IDO1 (0.52) | IDO1GAAMAPTMEN1KMT2A | |
| SCHEMBL27918261 | 0.65 | IDO1 (0.52) | IDO1GAAMAPTMEN1KMT2A | |
| SCHEMBL25288630 | 0.64 | HSD17B10 (0.56) | IDO1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL27404564 | 0.64 | MAPT (0.42) | GAAMAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906297-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049692-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-12-31 | — | — | WO | disclosed |