Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl 2,5-Dimethoxybenzoate SCHEMBL2091289 | 0.87 | MAPT (0.66) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL85785 | 0.83 | CA12 (0.62) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL31009365 | 0.76 | CA12 (0.67) | KDM4EMAPTHTTNPSR1ABCG2 | |
| SCHEMBL7619139 | 0.76 | CA12 (0.67) | KDM4EMAPTHTTNPSR1ABCG2 | |
| SCHEMBL28102504 | 0.76 | ABCG2 (0.50) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL2091287 | 0.76 | KDM4E (0.57) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29208993 | 0.75 | MAPT (0.47) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30009450 | 0.74 | KDM4E (0.80) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL22345013 | 0.74 | KDM4E (0.80) | KDM4ECYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1505444 | 0.74 | HSP90AA1 (0.57) | KDM4EMAPTHTTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051762-A1 | POLYCATIONIC COMPOUNDS AND USES THEREOF | POLYMEDIX, INC. | 2014-02-20 | — | — | US | disclosed |
| US-8507723-B2 | Polycationic compounds and uses thereof | POLYMEDIX, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20120322878-A1 | Polycationic Compounds And Uses Thereof | POLYMEDIX, INC. (US) | 2012-12-20 | — | — | US | disclosed |
| US-8232428-B2 | Polycationic compounds and uses thereof | PolyMedix,Inc. (US) | 2012-07-31 | — | — | US | disclosed |
| US-8129566-B2 | Polycationic compounds and uses thereof | POLYMEDIX, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110124664-A1 | Polycationic Compounds And Uses Thereof | POLYMEDIX, INC. (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322878-A1 | Polycationic Compounds And Uses Thereof | VEGFA, VHL, PGF | KDM4E 3274/4885CYP2C9 4770/4885CYP1A2 4597/4885 |
| US-20110124664-A1 | Polycationic Compounds And Uses Thereof | VEGFA, VHL, PGF | KDM4E 3274/4885CYP2C9 4770/4885CYP1A2 4597/4885 |
| US-20140051762-A1 | POLYCATIONIC COMPOUNDS AND USES THEREOF | VEGFA, VHL, PGF | KDM4E 3274/4885CYP2C9 4770/4885CYP1A2 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.