Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.62 |
| ▸ | CA1 | P00915 | 5/20 | 0.62 |
| ▸ | CA2 | P00918 | 5/20 | 0.62 |
| ▸ | CA7 | P43166 | 5/20 | 0.62 |
| ▸ | CA9 | Q16790 | 5/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl 2-Hydroxy-5-Methoxybenzoate SCHEMBL643758 | 0.84 | CA1 (0.72) | CA12CA1CA2CA7CA9 | |
| Methyl 2-Hydroxy-5-Methoxybenzoate SCHEMBL29709382 | 0.84 | CA1 (0.72) | CA12CA1CA2CA7CA9 | |
| SCHEMBL85830 | 0.83 | KDM4E (0.53) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| Methyl 2-Hydroxy-5-Methoxybenzoate SCHEMBL15767832 | 0.79 | CA12 (0.64) | CA12CA1CA2CA7CA9 | |
| SCHEMBL27444678 | 0.78 | CA12 (0.62) | CA12CA1CA2CA7CA9 | |
| Methyl 2,5-Dihydroxybenzoate SCHEMBL38890 | 0.77 | CA12 (1.00) | CA12CA1CA2CA7CA9 | |
| Methyl 2,5-Dihydroxybenzoate SCHEMBL29457577 | 0.77 | CA12 (1.00) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1316757 | 0.77 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8502531 | 0.77 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL20628874 | 0.75 | CA12 (0.59) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051762-A1 | POLYCATIONIC COMPOUNDS AND USES THEREOF | POLYMEDIX, INC. | 2014-02-20 | — | — | US | disclosed |
| US-8507723-B2 | Polycationic compounds and uses thereof | POLYMEDIX, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20120322878-A1 | Polycationic Compounds And Uses Thereof | POLYMEDIX, INC. (US) | 2012-12-20 | — | — | US | disclosed |
| US-8232428-B2 | Polycationic compounds and uses thereof | PolyMedix,Inc. (US) | 2012-07-31 | — | — | US | disclosed |
| US-8129566-B2 | Polycationic compounds and uses thereof | POLYMEDIX, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110124664-A1 | Polycationic Compounds And Uses Thereof | POLYMEDIX, INC. (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322878-A1 | Polycationic Compounds And Uses Thereof | VEGFA, VHL, PGF | CA12 432/4885CA1 1054/4885CA2 1348/4885 |
| US-20110124664-A1 | Polycationic Compounds And Uses Thereof | VEGFA, VHL, PGF | CA12 432/4885CA1 1054/4885CA2 1348/4885 |
| US-20140051762-A1 | POLYCATIONIC COMPOUNDS AND USES THEREOF | VEGFA, VHL, PGF | CA12 432/4885CA1 1054/4885CA2 1348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.