Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 11/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | CCKAR | P32238 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8585291 | 0.87 | TBXAS1 (0.48) | TBXAS1SMN1; SMN2PTGDR2CYP2C9ALDH1A1 | |
| SCHEMBL8581839 | 0.85 | TBXAS1 (0.46) | TBXAS1SMN1; SMN2PTGDR2CYP2C9ALDH1A1 | |
| SCHEMBL8583156 | 0.81 | TBXAS1 (0.64) | TBXAS1PTGDR2TBXA2R | |
| SCHEMBL8578685 | 0.80 | TBXAS1 (0.47) | TBXAS1SMN1; SMN2PTGDR2CYP2C9POLB | |
| SCHEMBL8584108 | 0.77 | TBXAS1 (0.45) | TBXAS1PTGDR2CYP2C9POLBALDH1A1 | |
| SCHEMBL8539577 | 0.75 | TBXAS1 (0.61) | TBXAS1PTGDR2CYP2C9ALDH1A1 | |
| SCHEMBL8542545 | 0.74 | TBXAS1 (0.88) | TBXAS1PTGDR2TBXA2R | |
| SCHEMBL8583185 | 0.74 | TBXAS1 (0.62) | TBXAS1SMN1; SMN2PTGDR2 | |
| SCHEMBL8581374 | 0.73 | TBXAS1 (0.48) | TBXAS1PTGDR2CYP2C9ALDH1A1 | |
| SCHEMBL8541824 | 0.72 | TBXAS1 (0.67) | TBXAS1PTGDR2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | claimed |