Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8583292 | 1.00 | TDP1 (0.63) | TDP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL9483425 | 0.92 | ALDH1A1 (0.55) | TDP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL12924442 | 0.92 | ALDH1A1 (0.55) | TDP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL14063051 | 0.88 | ALDH1A1 (0.51) | TDP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL29325087 | 0.88 | ALDH1A1 (0.51) | TDP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL20932097 | 0.88 | ALDH1A1 (0.51) | TDP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL14063002 | 0.88 | ALDH1A1 (0.51) | TDP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL14063044 | 0.88 | ALDH1A1 (0.51) | TDP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL4429220 | 0.87 | ALDH1A1 (0.65) | TDP1KMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL15259688 | 0.87 | LMNA (0.50) | TDP1KMT2AMEN1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998037056-A1 | PHENOXYPROPANOLAMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 1998-08-27 | — | — | WO | disclosed |
| WO-1998022480-A1 | PHOSPHORUS CONTAINING ARYLOXY OR ARYLTHIO PROPANOLAMINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1998-05-28 | — | — | WO | disclosed |