Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 5/20 | 0.70 |
| ▸ | DHFR | P00374 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056693 | 0.99 | TK1 (0.72) | TK1DHFRPOLB | |
| SCHEMBL14682231 | 0.99 | TK1 (0.72) | TK1DHFRPOLB | |
| SCHEMBL2056695 | 0.99 | TK1 (0.72) | TK1DHFRPOLB | |
| Hydrochloric Acid SCHEMBL8585203 | 0.97 | TK1 (0.70) | TK1DHFRPOLB | |
| SCHEMBL17236359 | 0.92 | TK1 (0.67) | TK1DHFRPOLB | |
| SCHEMBL12718422 | 0.92 | TK1 (0.67) | TK1DHFRPOLB | |
| SCHEMBL12718420 | 0.91 | TK1 (0.66) | TK1DHFR | |
| SCHEMBL14590480 | 0.86 | TK1 (0.59) | TK1DHFR | |
| SCHEMBL7200634 | 0.85 | TK1 (0.69) | TK1DHFRPOLB | |
| SCHEMBL8883822 | 0.85 | TK1 (0.69) | TK1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767668-A4 | POLYNUCLEOSIDE CHAIN HAVING MULTIPLE NUCLEOSIDES, THE NUCLEOSIDES COUPLED BY GUANIDYL LINKAGES | UNIV CALIFORNIA (US) | 1998-04-08 | — | — | EP | disclosed |
| EP-0767668-A1 | POLYNUCLEOSIDE CHAIN HAVING MULTIPLE NUCLEOSIDES, THE NUCLEOSIDES COUPLED BY GUANIDYL LINKAGES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000575-A1 | POLYNUCLEOSIDE CHAIN HAVING MULTIPLE NUCLEOSIDES, THE NUCLEOSIDES COUPLED BY GUANIDYL LINKAGES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-01-11 | — | — | WO | disclosed |