Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051969 | 0.81 | CYP2C19 (0.50) | CYP2C19SMN1; SMN2APAF1CYP2D6SRC | |
| SCHEMBL1716112 | 0.81 | CYP2C19 (0.53) | CYP2C19SMN1; SMN2APAF1CYP2D6SRC | |
| SCHEMBL7973743 | 0.80 | CYP2C19 (0.61) | CYP2C19SMN1; SMN2CYP2D6SRCPOLB | |
| SCHEMBL27659178 | 0.79 | CYP2C19 (0.52) | CYP2C19SMN1; SMN2APAF1CYP2D6SRC | |
| SCHEMBL2872818 | 0.79 | APAF1 (0.53) | CYP2C19SMN1; SMN2APAF1CYP2D6SRC | |
| SCHEMBL8583905 | 0.78 | CYP2C19 (0.50) | CYP2C19SMN1; SMN2APAF1CYP2D6SRC | |
| SCHEMBL28980645 | 0.77 | MEN1 (0.49) | CYP2C19SMN1; SMN2POLBLMNA | |
| SCHEMBL9108453 | 0.77 | CYP2C19 (0.53) | CYP2C19SMN1; SMN2APAF1CYP2D6SRC | |
| SCHEMBL10150939 | 0.77 | CYP2C19 (0.57) | CYP2C19SMN1; SMN2CYP2D6SRCPOLB | |
| SCHEMBL18098108 | 0.76 | CYP2C19 (0.49) | CYP2C19SMN1; SMN2APAF1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603229-B1 | QUINUCLIDINE ESTERS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LTD (GB) | 1998-06-10 | — | — | EP | disclosed |
| US-5543419-A | TREATING CHRONIC OBSTRUCTIVE AIRWAYS DISEASE OR ASTHMA; ANTIMUSCARINIC BRONCHODILATOR AGENTS | PFIZER INC (US) | 1996-08-06 | — | — | US | disclosed |
| EP-0603229-A1 | QUINUCLIDINE ESTERS PROCESS AND INTERMEDIATE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1994-06-29 | — | — | EP | disclosed |
| WO-1993006098-A1 | QUINUCLIDINE ESTERS PROCESS AND INTERMEDIATE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |