Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28286023 | 0.87 | KDM4E (0.45) | KDM4EALDH1A1MAPK1SMN1; SMN2PARP15 | |
| SCHEMBL406268 | 0.85 | HTT (0.49) | KDM4EALDH1A1MAPK1SMN1; SMN2PLK1 | |
| SCHEMBL976330 | 0.85 | KDM4E (0.57) | KDM4EALDH1A1MAPK1SMN1; SMN2ALOX15 | |
| SCHEMBL10892729 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1MAPK1SMN1; SMN2PLK1 | |
| SCHEMBL3741758 | 0.83 | KDM4E (0.60) | KDM4EALDH1A1MAPK1SMN1; SMN2PLK1 | |
| SCHEMBL27789847 | 0.83 | SLC9A1 (0.47) | KDM4EALDH1A1MAPK1SMN1; SMN2PLK1 | |
| SCHEMBL3110545 | 0.81 | PLK1 (0.43) | KDM4EALDH1A1SMN1; SMN2PLK1MEN1 | |
| SCHEMBL5963042 | 0.81 | HMGCR (0.53) | KDM4EALDH1A1MAPK1SMN1; SMN2PLK1 | |
| Hydrochloric Acid SCHEMBL5963255 | 0.80 | KDM4E (0.40) | KDM4EALDH1A1MAPK1SMN1; SMN2PLK1 | |
| SCHEMBL23535584 | 0.80 | HPGDS (0.66) | KDM4EALDH1A1MAPK1SMN1; SMN2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590063-A | DIMETHOXY NAPHTHALENE CARBOXAMIDES | ADRIA LABORATORIES, INC. (US) | 1986-05-20 | — | — | US | claimed |
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | disclosed |
| US-4590063-A | DIMETHOXY NAPHTHALENE CARBOXAMIDES | ADRIA LABORATORIES, INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4540814-A | 1,4-Dimethoxy naphthalenecarboxamide anticonvulsants | ADRIA LABORATORIES, INC. (US) | 1985-09-10 | — | — | US | disclosed |