Pyridine

Pyridine

SCHEMBL8587106

c1cc2scnc2cn1.c1ccncc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.48
HSD17B10 Q99714 1/20 0.48
NAMPT P43490 2/20 0.43
GFER P55789 1/20 0.37
AURKA O14965 1/20 0.36
CYP2A6 P11509 2/20 0.35
CYP2E1 P05181 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2B6 P20813 1/20 0.35
TDP1 Q9NUW8 2/20 0.35
KDM4E B2RXH2 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
HKDC1 Q2TB90 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
FGFR1 P11362 1/20 0.34
RIPK2 O43353 1/20 0.34
RIPK1 Q13546 1/20 0.33
CYP19A1 P11511 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL89139 0.90
Hydrochloric Acid SCHEMBL31194817 0.88 ALDH1A1 (0.50) ALDH1A1HSD17B10NAMPTGFERAURKA
SCHEMBL10968213 0.83 ALDH1A1 (0.50) ALDH1A1HSD17B10NAMPTGFERAURKA
Benzo[D]Thiazole SCHEMBL27798130 0.81 ALDH1A1 (0.76) ALDH1A1HSD17B10NAMPTGFERAURKA
Benzo[D]Thiazole SCHEMBL28087325 0.79 ALDH1A1 (0.73) ALDH1A1HSD17B10NAMPTGFERAURKA
SCHEMBL10828 0.74
SCHEMBL29600620 0.74
Hydrochloric Acid SCHEMBL30834436 0.72 ALDH1A1 (0.50) ALDH1A1HSD17B10NAMPTGFERAURKA
Benzo[D]Thiazole SCHEMBL27256307 0.72 ALDH1A1 (0.83) ALDH1A1HSD17B10NAMPTGFERAURKA
Benzo[D]Thiazole SCHEMBL28600155 0.69 ALDH1A1 (0.76) ALDH1A1HSD17B10NAMPTGFERAURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0462009-B1 Cephalosporins having in position 3 a propenyl radical substituted by a quaternary ammonium, their process for preparation, their use as medicaments, compositions containing them and intermediates HOECHST MARION ROUSSEL INC (FR) 1998-10-28 EP disclosed