Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116709 | 0.96 | CPA1 (0.55) | CPA1ALDH1A1TSHR | |
| SCHEMBL11875036 | 0.80 | CPA1 (0.44) | CPA1ALDH1A1TSHR | |
| Nitric Acid SCHEMBL9131176 | 0.79 | CPA1 (0.50) | CPA1CA5ACA5BALDH1A1TSHR | |
| SCHEMBL5467078 | 0.75 | ALDH1A1 (0.41) | CPA1CA5ACA5BALDH1A1TSHR | |
| SCHEMBL3789231 | 0.74 | CPA1 (0.52) | CPA1ALDH1A1TSHR | |
| SCHEMBL6578335 | 0.72 | CPA1 (0.37) | CPA1ALDH1A1 | |
| SCHEMBL8587453 | 0.72 | CPA1 (0.38) | CPA1ALDH1A1 | |
| SCHEMBL5356077 | 0.72 | — | — | |
| SCHEMBL18463625 | 0.72 | CPA1 (0.54) | CPA1TSHR | |
| SCHEMBL6927866 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952375-A | NEURAMINIDASE INHIBITOR FOR INHIBITION OF VIRUSES, IN PARTICULAR INFLUENZA VIRUSES; FDA ORANGE BOOK LISTED PATENT FOR OSELTAMIVIR PHOSPHATE | GILEAD SCIENCES, INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5763483-A | NEURAMINIDASE INHIBITOR TREATING INFLUENZA VIRUS INFECTION; OSELTAMIVIR OR THE FREE ACID THEREOF; FDA ORANGE BOOK LISTED PATENT FOR OSELTAMIVIR PHOSPHATE | GILEAD SCIENCES, INC. (US) | 1998-06-09 | — | — | US | disclosed |