Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.37 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.37 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | GGH | Q92820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139 | 0.92 | KMT2A (0.50) | MMP2MMP9L3MBTL1CA2CA1 | |
| SCHEMBL8140 | 0.92 | KMT2A (0.50) | MMP2MMP9L3MBTL1CA2CA1 | |
| SCHEMBL154381 | 0.92 | KMT2A (0.50) | MMP2MMP9L3MBTL1CA2CA1 | |
| Hydrochloric Acid SCHEMBL23834101 | 0.90 | KMT2A (0.48) | MMP2MMP9L3MBTL1CA2CA1 | |
| Hydrochloric Acid SCHEMBL22978412 | 0.90 | KMT2A (0.48) | MMP2MMP9L3MBTL1CA2CA1 | |
| SCHEMBL30423570 | 0.90 | KMT2A (0.48) | MMP2MMP9L3MBTL1CA2CA1 | |
| Hydrochloric Acid SCHEMBL5408064 | 0.90 | KMT2A (0.48) | MMP2MMP9L3MBTL1CA2CA1 | |
| SCHEMBL12611809 | 0.87 | FOLH1 (0.52) | MMP2MMP9KMT2APMP22ALOX15 | |
| SCHEMBL12611816 | 0.87 | FOLH1 (0.52) | MMP2MMP9KMT2APMP22ALOX15 | |
| Phosphoric Acid SCHEMBL8519199 | 0.85 | GGH (0.47) | MMP2MMP9L3MBTL1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756351-A | Biomolecular optical sensors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-05-26 | — | — | US | disclosed |