Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587811 | 1.00 | MAPT (0.51) | MAPTKMT2AGAALMNAMEN1 | |
| SCHEMBL14058831 | 0.86 | MAPT (0.51) | MAPTKMT2AGAALMNAMEN1 | |
| SCHEMBL14058830 | 0.86 | MAPT (0.51) | MAPTKMT2AGAALMNAMEN1 | |
| SCHEMBL8588829 | 0.82 | ACACB (0.39) | MAPTKMT2AGAALMNAMEN1 | |
| SCHEMBL8588832 | 0.82 | ACACB (0.39) | MAPTKMT2AGAALMNAMEN1 | |
| SCHEMBL6222383 | 0.82 | MAPT (0.48) | MAPTKMT2AGAALMNAMEN1 | |
| SCHEMBL5253849 | 0.81 | MAPT (0.47) | MAPTKMT2AGAALMNAMEN1 | |
| SCHEMBL1144594 | 0.81 | RAB9A (0.53) | MAPTKMT2AGAAMEN1ALDH1A1 | |
| SCHEMBL5448837 | 0.80 | KYAT1 (0.50) | MAPTKMT2AGAALMNAMEN1 | |
| SCHEMBL5448834 | 0.80 | KYAT1 (0.50) | MAPTKMT2AGAALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810864-A4 | 2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY | MERCK & CO INC (US) | 1998-03-04 | — | — | EP | disclosed |
| EP-0810864-A1 | 2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY | Merck & Co., Inc. (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5670504-A | 2,6-diaryl pyridazinones with immunosuppressant activity | MERCK & CO. INC. (US) | 1997-09-23 | — | — | US | disclosed |