Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 7/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588039 | 1.00 | MAP4K1 (0.44) | MAP4K1NTRK1SIRT1LRRK2TLK2 | |
| SCHEMBL8529701 | 0.83 | KDM4E (0.47) | NTRK1LRRK2RETKDRIGF1R | |
| SCHEMBL5361502 | 0.82 | PDPK1 (0.64) | NTRK1TLK2PDPK1PAK4RET | |
| SCHEMBL8584320 | 0.81 | NTRK1 (0.47) | MAP4K1NTRK1SIRT1TLK2PDPK1 | |
| SCHEMBL8584332 | 0.81 | NTRK1 (0.47) | MAP4K1NTRK1SIRT1TLK2PDPK1 | |
| SCHEMBL3485635 | 0.80 | TLK2 (0.64) | MAP4K1NTRK1SIRT1LRRK2TLK2 | |
| SCHEMBL8586257 | 0.80 | NTRK1 (0.57) | MAP4K1NTRK1LRRK2PDPK1PAK4 | |
| SCHEMBL8586259 | 0.80 | NTRK1 (0.57) | MAP4K1NTRK1LRRK2PDPK1PAK4 | |
| SCHEMBL5364426 | 0.77 | RET (0.67) | NTRK1TLK2PDPK1PAK4LCK | |
| SCHEMBL8528465 | 0.76 | DHFR (0.42) | NTRK1TLK2PDPK1PAK4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | claimed |
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |