SCHEMBL858818

SCHEMBL858818

C=CCC(=O)[C@H](O)[C@H](O)[C@H](O)CO

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.43
LMNA P02545 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
USP2 O75604 1/20 0.36
SLCO1B1 Q9Y6L6 1/20 0.36
CYP2C9 P11712 1/20 0.34
TSHR P16473 1/20 0.34
KDM4E B2RXH2 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1843798 1.00 PDE4A (0.43) PDE4ALMNAL3MBTL1TDP1USP2
SCHEMBL28292381 1.00 PDE4A (0.43) PDE4ALMNAL3MBTL1TDP1USP2
SCHEMBL18825591 1.00 PDE4A (0.43) PDE4ALMNAL3MBTL1TDP1USP2
SCHEMBL27438858 0.94 PDE4A (0.52) PDE4ALMNAL3MBTL1TDP1USP2
SCHEMBL1704734 0.94 PDE4A (0.52) PDE4ALMNAL3MBTL1TDP1USP2
SCHEMBL1062215 0.94 PDE4A (0.52) PDE4ALMNAL3MBTL1TDP1USP2
SCHEMBL8658675 0.92 PDE4A (0.50) PDE4ALMNAL3MBTL1TDP1USP2
Bicarbonate SCHEMBL30050792 0.90 PDE4A (0.53) PDE4ALMNAL3MBTL1TDP1USP2
Acrylamide SCHEMBL6682076 0.86 PDE4A (0.44) PDE4ALMNAL3MBTL1TDP1USP2
Fructose SCHEMBL9263130 0.79 CYP2C9 (0.48) PDE4ALMNAL3MBTL1TDP1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220195424-A1 Chemical Capping for Template Switching NEW ENGLAND BIOLABS, INC. (US) 2022-06-23 US claimed
US-9994856-B2 Method for increasing the activity of a cystic fibrosis transmembrane conductance regulator protein PROQR THERAPEUTICS II B.V. (NL) 2018-06-12 US claimed
US-20170152518-A1 OLIGONUCLEOTIDES FOR MAKING A CHANGE IN THE SEQUENCE OF A TARGET RNA MOLECULE PRESENT IN A LIVING CELL PROQR THERAPEUTICS B.V. (NL) 2017-06-01 US claimed
US-9605255-B2 Oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell PROQR THERAPEUTICS II B.V. (NL) 2017-03-28 US claimed
EP-2852668-B1 OLIGONUCLEOTIDES FOR MAKING A CHANGE IN THE SEQUENCE OF A TARGET RNA MOLECULE PRESENT IN A LIVING CELL PROQR THERAPEUTICS II BV (NL) 2016-04-27 EP claimed
US-20150197744-A1 OLIGONUCLEOTIDES FOR MAKING A CHANGE IN THE SEQUENCE OF A TARGET RNA MOLECULE PRESENT IN A LIVING CELL PROQR THERAPEUTICS II B.V. (NL) 2015-07-16 US claimed
EP-2852668-A1 OLIGONUCLEOTIDES FOR MAKING A CHANGE IN THE SEQUENCE OF A TARGET RNA MOLECULE PRESENT IN A LIVING CELL ProQR Therapeutics B.V. (NL) 2015-04-01 EP claimed
WO-2014011053-A1 OLIGONUCLEOTIDES FOR MAKING A CHANGE IN THE SEQUENCE OF A TARGET RNA MOLECULE PRESENT IN A LIVING CELL PROQR THERAPEUTICS B.V. (NL) 2014-01-16 WO claimed
JP-4836327-B2 2011-12-14 JP claimed
CN-100389196-C Cancer cell vaccine ANTIGEN EXPRESS INC (US) 2008-05-21 CN claimed
US-20030054365-A1 MHC class II antigen presenting cells containing oligonucleotides which inhibit Ii protein expression ANTIGEN EXPRESS, INC. 2003-03-20 US claimed
JP-2002531582-A 2002-09-24 JP claimed
US-6368855-B1 A CELL CONTAINING A SPECIFIC REGULATOR OF AN INVARIANT CHAIN PROTEIN AND CAN HYBRIDIZE TO SPECIFIC TARGET RNA REGIONS UNDER PHYSIOLOGICAL CONDITIONS DUE TO A COPOLYMER ANTIGEN EXPRESS, INC. 2002-04-09 US claimed
CN-1332799-A Cancer cell vaccine ANTIGEN EXPRESS INC (US) 2002-01-23 CN claimed
EP-1135482-A1 CANCER CELL VACCINE Antigen Express, Inc. (US) 2001-09-26 EP claimed
CN-1060781-C Phosphonootropic monoester nucleic acids, process for their preparation and their use HOECHST AG (DE) 2001-01-17 CN claimed
WO-2000034467-A1 CANCER CELL VACCINE ANTIGEN EXPRESS, INC. (US) 2000-06-15 WO claimed
CN-1138588-A Phosphonootropic monoester nucleic acids, process for their preparation and their use HOECHST AG (DE) 1996-12-25 CN claimed
US-5587469-A USEFUL AS ?ANTISENSE AGENTS? THAT ARE CAPABLE OF SPECIFIC HYBRIDIZATION WITH A NUCLEOTIDE SEQUENCE OF AN RNA ISIS PHARMACEUTICALS, INC. (US) 1996-12-24 US claimed
US-4469863-A ANTITUMOR AGENTS, VIRICIDES GENTA INCORPORATED 1984-09-04 US claimed