Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062215 | 0.96 | PDE4A (0.52) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| SCHEMBL1704734 | 0.96 | PDE4A (0.52) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| SCHEMBL27438858 | 0.96 | PDE4A (0.52) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| SCHEMBL8658675 | 0.94 | PDE4A (0.50) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| SCHEMBL18825591 | 0.90 | PDE4A (0.43) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| SCHEMBL1843798 | 0.90 | PDE4A (0.43) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| SCHEMBL28292381 | 0.90 | PDE4A (0.43) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| SCHEMBL858818 | 0.90 | PDE4A (0.43) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Acrylamide SCHEMBL6682076 | 0.88 | PDE4A (0.44) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Palmitic Acid SCHEMBL28788074 | 0.81 | GPR84 (0.45) | PDE4ALMNAUSP2TDP1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022181930-A1 | COATING SOLUTION FOR COLORED CONTACT LENS, PREPARATION METHOD THEREFOR, AND COLORED CONTACT LENS PREPARED BY COMPRISING SAME | 주식회사 아이코디 | 2022-09-01 | — | — | WO | disclosed |