Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588419 | 1.00 | HSD17B10 (0.44) | HSD17B10TP53TDP1SMN1; SMN2KDM4E | |
| SCHEMBL21564929 | 0.83 | SPHK2 (0.33) | SHBG | |
| SCHEMBL175125 | 0.77 | TP53 (0.41) | TP53SMN1; SMN2KDM4EGMNNLMNA | |
| SCHEMBL12321734 | 0.77 | TP53 (0.41) | TP53SMN1; SMN2KDM4EGMNNLMNA | |
| SCHEMBL21155241 | 0.74 | TP53 (0.38) | TP53SMN1; SMN2KDM4EGMNNLMNA | |
| SCHEMBL28432329 | 0.74 | HSD17B10 (0.47) | HSD17B10TDP1SMN1; SMN2 | |
| SCHEMBL16754247 | 0.74 | KDM4E (0.44) | HSD17B10TDP1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL13568045 | 0.73 | HSD17B10 (0.67) | HSD17B10TDP1LMNAMAPT | |
| SCHEMBL24022476 | 0.73 | SHBG (0.33) | SMN1; SMN2SHBG | |
| SCHEMBL16754251 | 0.72 | KDM4E (0.45) | HSD17B10SMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050031-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |