Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4658526 | 0.82 | MAPT (0.60) | KMT2AMEN1PDE10AKDM4EALDH1A1 | |
| SCHEMBL28002003 | 0.81 | MEN1 (0.55) | KMT2AMEN1PDE10AKDM4ENPC1 | |
| SCHEMBL28001704 | 0.80 | DHFR (0.58) | SMN1; SMN2MAPTABCB1 | |
| SCHEMBL27371075 | 0.80 | CYSLTR1 (0.49) | PDE10ASIGMAR1CYP1A2 | |
| SCHEMBL22209200 | 0.80 | FFAR1 (0.55) | PKMKMT2AMEN1NOD2PDE10A | |
| SCHEMBL28002107 | 0.78 | DHFR (0.58) | KMT2AMEN1PDE10ASMN1; SMN2CYP1A2 | |
| SCHEMBL18546229 | 0.78 | FFAR1 (0.48) | PDE10A | |
| SCHEMBL1695565 | 0.77 | AKT1 (0.51) | PKMKMT2AMEN1NOD2PDE10A | |
| SCHEMBL10547704 | 0.76 | PDE10A (0.64) | PDE10ACYP1A2 | |
| SCHEMBL2913941 | 0.76 | PDE10A (0.61) | PDE10ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606380-B1 | 2-SUBSTITUTED QUINOLINES FOR TREATING LEISHMANIOSES | ORSTOM (FR) | 1998-11-25 | — | — | EP | disclosed |
| US-5541196-A | ANTIPROTOZOA AGENTS | INSTITUT FRANCAIS DE RECHERCHE SCIENTIFIQUE POUR LE DEVELOPPMENT EN COOPERATION (ORSTOM) (FR) | 1996-07-30 | — | — | US | disclosed |
| EP-0606380-A1 | 2-SUBSTITUTED QUINOLINES FOR TREATING LEISHMANIOSES | INSTITUT FRANCAIS DE RECHERCHE SCIENTIFIQUE POUR LE DEVELOPPEMENT EN COOPERATION (ORSTOM) (FR) | 1994-07-20 | — | — | EP | disclosed |
| WO-1993007125-A1 | 2-SUBSTITUTED QUINOLINES FOR TREATING LEISHMANIOSES | INSTITUT FRANÇAIS DE RECHERCHE SCIENTIFIQUE POUR LE DEVELOPPEMENT EN COOPERATION (ORSTOM) (FR) | 1993-04-15 | — | — | WO | disclosed |