Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506644 | 0.87 | PTGS2 (0.63) | PTGS2PTGS1APPCYP2C19AKR1C3 | |
| SCHEMBL27608745 | 0.83 | PTGS1 (0.59) | PTGS2PTGS1KMT2AAKR1C3 | |
| SCHEMBL5018932 | 0.80 | ALDH1A1 (0.43) | PTGS2PTGS1ALDH1A1KMT2APARP10 | |
| SCHEMBL19182930 | 0.79 | PTGS1 (0.54) | PTGS2PTGS1KMT2ACYP2C19AKR1C3 | |
| SCHEMBL19182931 | 0.79 | PTGS1 (0.54) | PTGS2PTGS1KMT2ACYP2C19AKR1C3 | |
| SCHEMBL31117279 | 0.79 | PTGS1 (0.54) | PTGS2PTGS1KMT2ACYP2C19AKR1C3 | |
| SCHEMBL16216398 | 0.78 | PTGS1 (1.00) | PTGS2PTGS1APP | |
| SCHEMBL16207587 | 0.78 | PTGS1 (1.00) | PTGS2PTGS1APP | |
| SCHEMBL16207512 | 0.77 | PTGS2 (0.52) | PTGS2PTGS1KMT2ACYP2C19AKR1C3 | |
| SCHEMBL16219361 | 0.77 | PTGS1 (0.52) | PTGS2PTGS1KMT2AAPPCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998057910-A2 | CYCLOOXYGENASE-I SELECTIVE INHIBITORS AND THE USE THEREOF AS ANALGESIC, ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS | LABORATORIOS MENARINI S.A. (ES) | 1998-12-23 | — | — | WO | claimed |
| WO-1998057910-A2 | CYCLOOXYGENASE-I SELECTIVE INHIBITORS AND THE USE THEREOF AS ANALGESIC, ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS | LABORATORIOS MENARINI S.A. (ES) | 1998-12-23 | — | — | WO | disclosed |