Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587428 | 0.82 | ALDH1A1 (0.44) | MAPTGAACYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL31568215 | 0.77 | GAA (0.50) | MAPTMGLLGAACYP1A2CYP2D6 | |
| SCHEMBL7560936 | 0.76 | GAA (0.49) | MAPTGAAALDH1A1POLBKMT2A | |
| SCHEMBL7508432 | 0.73 | MAPT (0.61) | MAPTGAABCL9CTNNB1ALDH1A1 | |
| SCHEMBL23122921 | 0.73 | ALDH1A1 (0.57) | MAPTMGLLGAAALDH1A1KDM4E | |
| SCHEMBL29795626 | 0.73 | ALDH1A1 (0.57) | MAPTMGLLGAAALDH1A1KDM4E | |
| SCHEMBL28299076 | 0.72 | MGLL (0.49) | MGLLGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL24729670 | 0.72 | CYP1A2 (0.54) | MGLLCYP1A2CYP2D6FAAH | |
| SCHEMBL29014065 | 0.71 | CYP19A1 (0.49) | MAPTMGLLGAACYP1A2CYP2D6 | |
| SCHEMBL7590176 | 0.70 | GAA (0.51) | MAPTMGLLGAACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998051311-A2 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-11-19 | — | — | WO | disclosed |