Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 13/20 | 0.49 |
| ▸ | BCHE | P06276 | 5/20 | 0.49 |
| ▸ | ACHE | P22303 | 5/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9092986 | 0.81 | L3MBTL1 (0.64) | ATML3MBTL1MEN1KMT2ACHRM2 | |
| SCHEMBL6555197 | 0.81 | MEN1 (0.66) | ATML3MBTL1MEN1KMT2ACHRM2 | |
| SCHEMBL8589748 | 0.78 | L3MBTL1 (0.53) | ATML3MBTL1MEN1KMT2ACHRM5 | |
| SCHEMBL8593599 | 0.77 | L3MBTL1 (0.52) | ATML3MBTL1MEN1KMT2ACHRM5 | |
| SCHEMBL8592466 | 0.77 | L3MBTL1 (0.52) | ATML3MBTL1MEN1KMT2ACHRM5 | |
| SCHEMBL8138468 | 0.77 | CHRM2 (0.72) | MEN1KMT2ACHRM2BCHEACHE | |
| Hydrochloric Acid SCHEMBL9351001 | 0.76 | CHRM2 (0.73) | MEN1KMT2ACHRM2BCHEACHE | |
| Hydrochloric Acid SCHEMBL4354687 | 0.76 | CHRM2 (0.73) | MEN1KMT2ACHRM2BCHEACHE | |
| SCHEMBL8591350 | 0.75 | ATM (0.59) | ATML3MBTL1MEN1KMT2ACHRM2 | |
| SCHEMBL8593004 | 0.75 | ATM (0.52) | ATML3MBTL1MEN1KMT2ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613458-B1 | ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS | PFIZER (US) | 1998-01-07 | — | — | EP | claimed |
| JP-2614408-B2 | — | — | 1997-05-28 | — | — | JP | claimed |
| WO-1993010073-A1 | ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1993-05-27 | — | — | WO | claimed |
| EP-0613458-B1 | ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS | PFIZER (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5521220-A | Acyclic ethylenediamine derivatives | PFIZER INC. (US) | 1996-05-28 | — | — | US | disclosed |
| WO-1993010073-A1 | ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1993-05-27 | — | — | WO | disclosed |