Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1226216 | 0.81 | SIGMAR1 (0.49) | SIGMAR1MTNR1AMTNR1BTBXAS1CHRNB2 | |
| SCHEMBL6897257 | 0.77 | SIGMAR1 (0.54) | SIGMAR1MTNR1AMTNR1BTBXAS1ESR1 | |
| SCHEMBL9092744 | 0.76 | SIGMAR1 (0.53) | SIGMAR1MTNR1AMTNR1BTBXAS1CHRNB2 | |
| SCHEMBL8094515 | 0.76 | SIGMAR1 (0.53) | SIGMAR1TBXAS1ESR1ESR2 | |
| SCHEMBL251740 | 0.76 | SIGMAR1 (0.44) | SIGMAR1MTNR1AMTNR1BTBXAS1CHRNB2 | |
| SCHEMBL11792681 | 0.74 | TBXAS1 (0.54) | SIGMAR1TBXAS1ESR1ESR2 | |
| SCHEMBL11229130 | 0.74 | TBXAS1 (0.54) | SIGMAR1TBXAS1ESR1ESR2 | |
| SCHEMBL8418666 | 0.74 | TBXAS1 (0.54) | SIGMAR1TBXAS1ESR1ESR2 | |
| SCHEMBL9169660 | 0.74 | TBXAS1 (0.54) | SIGMAR1TBXAS1ESR1ESR2 | |
| SCHEMBL7861116 | 0.74 | TBXAS1 (0.54) | SIGMAR1TBXAS1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646569-B1 | Novel carboxylate derivatives exhibiting phospholipase A2 inhibitory activity | SHIONOGI & CO (JP) | 1998-01-07 | — | — | EP | disclosed |
| EP-0646569-A1 | Novel carboxylate derivatives exhibiting phospholipase A2 inhibitory activity | SHIONOGI & CO., LTD. (JP) | 1995-04-05 | — | — | EP | disclosed |