Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8595758 | 1.00 | KEAP1 (0.45) | KEAP1NFE2L2CNR1CNR2PSMB8 | |
| SCHEMBL8445031 | 0.93 | KEAP1 (0.40) | KEAP1NFE2L2CNR1CNR2PSMB8 | |
| SCHEMBL8444977 | 0.91 | CNR2 (0.53) | KEAP1NFE2L2CNR1CNR2PSMB8 | |
| SCHEMBL8444975 | 0.91 | CNR2 (0.53) | KEAP1NFE2L2CNR1CNR2PSMB8 | |
| SCHEMBL4426111 | 0.86 | ALDH1A1 (0.51) | MAPTMMEHPGDPSEN1PSEN2 | |
| SCHEMBL4426109 | 0.86 | ALDH1A1 (0.51) | MAPTMMEHPGDPSEN1PSEN2 | |
| SCHEMBL7157324 | 0.83 | MME (0.43) | MAPTMMEPSEN1PSEN2APH1B | |
| SCHEMBL4552318 | 0.82 | HPGD (0.55) | KEAP1NFE2L2CNR1CNR2PSMB8 | |
| SCHEMBL4415496 | 0.82 | HPGD (0.55) | KEAP1NFE2L2CNR1CNR2PSMB8 | |
| SCHEMBL4414750 | 0.81 | POLB (0.54) | CNR1CNR2PSMB8PSMB5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998022430-A9 | N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING b-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | — | 1998-08-20 | — | — | WO | claimed |